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Skip to contentIf you or someone you know needs substance abuse treatment in Sioux Falls, South Dakota, confidential help is available 24/7 at no cost.
The following 11 facilities are registered with the Substance Abuse and Mental Health Services Administration (SAMHSA). This is a factual directory listing — not an endorsement. Call ahead to confirm availability, services, and insurance acceptance.
📍 4320 South Louise Avenue, Sioux Falls, SD 57106
Intensive Outpatient Outpatient
📍 4109 South Carnegie Circle, Sioux Falls, SD 57106
Outpatient
📍 3800 South Kiwanis Avenue, Sioux Falls, SD 57105
Intensive Outpatient Outpatient
📍 4000 South West Avenue, Sioux Falls, SD 57105
Residential
📍 3930 South West Avenue, Sioux Falls, SD 57105
Residential Intensive Outpatient Outpatient
📍 1310 West 51st Street, Sioux Falls, SD 57105
Residential Intensive Outpatient Outpatient
📍 2519 West 8th Street, Sioux Falls, SD 57104
Outpatient Medication-Assisted
📍 822 East 41st Street, Sioux Falls, SD 57105
Outpatient
📍 Avera Professional Plaza, Sioux Falls, SD 57105
Intensive Outpatient Outpatient
📍 2601 South Minnesota Avenue, Sioux Falls, SD 57105
Residential
Intensive Outpatient Outpatient
Source: SAMHSA National Directory of Drug and Alcohol Abuse Treatment Programs. Data is provided for informational purposes only. FindTreatment.gov